CELL SPECIFIC LABELING OF NEWLY SYNTHESIZED PROTEINS

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United States of America Patent

APP PUB NO 20160176919A1
SERIAL NO

14978700

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Disclosed herein are compositions comprising blocked puromycin analogs that are converted into active puromycin analogs upon the activity of a penicillin acylase. Also disclosed are methods of using blocked puromycin analogs to label proteins in a selected cell type in vivo in a transgenic multicellular organism that expresses a penicillin acylase within the selected cell type. Also disclosed are transgenic mice expressing a penicillin acylase within a selected cell type.

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Patent Owner(s)

Patent OwnerAddress
OREGON HEALTH & SCIENCE UNIVERSITYORE OREGON

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barrett, Ruth Portland, US 2 1
Cohen, Michael Portland, US 145 4327
Jin, Haihong Portland, US 18 89

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