Compositions and Methods of Treatment of Corneal Endothelium Disorders
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United States of America Patent
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Jun 23, 2016
app pub date -
Dec 31, 2015
filing date -
Dec 31, 2015
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Abstract
This application discloses pharmaceutical compositions (e.g., oral, parenteral or topical ophthalmic formulations) for treating Fuchs endothelial corneal dystrophy (FECD) with one or more Nrf2 activators and/or mitochondrially targeted antioxidants. The compositions may be topically administered to the eye and are effective in the treatment of FECD. The invention further provides methods of treating FECD by in a subject in need of such treatment by topical application of one or more Nrf2 activators and/or mitochondrially of the invention.
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