ASSAY STRUCTURES AND ENHANCEMENT BY SELECTIVE MODIFICATION AND BINDING ON AMPLIFICATION STRUCTURES
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United States of America Patent
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Jun 16, 2016
app pub date -
Dec 9, 2015
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Dec 10, 2014
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Abstract
The invention is related to the methods, devices, fabrications and applications that can improve the property of assay sensing an analyte by selectively masking the surface and selectively bonding in an assay which has high sensing signal amplification surfaces and low sensing signal amplification surfaces. The sensing includes Raman scattering, chromaticity, luminescence that includes fluorescence, electroluminescence, chemiluminescence, and electrochemiluminescence. The sensing property includes the sensing signal intensity, sensing signal spectrum, limit of detection, detection dynamic range, and signal variation reduction (smaller error bar) of the sensing. The invention can be used in the sensing in vitro, or in vivo.
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