Importance

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Abstract

Provided are methods and materials for treating a neurological, behavioural, psychological, psychiatric, or personality disorder or syndrome in an individual, which disorder or syndrome is associated with a plurality of aberrant thoughts, behaviors and/or dispositions to behaviour. The methods comprise (i) selecting an individual suffering from, or believed to suffer from, said disorder or syndrome; and (ii) selecting a set of effector junctions in the individual, wherein at least one of said aberrant thoughts, behaviors or dispositions is modifiable by modulation of transmission across the set of effector junctions; (iii) treating the individual with an agent (for example botulinum toxin or a derivative or analog thereof) or intervention which causes blockade of or interference with the set of effector junctions, wherein blockade of the set of effector junctions results in an inhibition of the plurality of aberrant thoughts, behaviors and/or dispositions associated with the disorder.

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First Claim