HYPHOMICROBIUM SP. MICROORGANISM AND METHOD OF PRODUCING PYRROLOQUINOLINE QUINONE USING THE SAME
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Jun 9, 2016
app pub date -
Dec 3, 2015
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Dec 5, 2014
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Provided are a Hyphomicrobium sp. mutant strain SWB-P91 (KCTC12695BP) having high productivity of pyrroloquinoline quinone, and a method of producing a Hyphomicrobium sp. mutant strain SWB-P91 (KCTC12695BP), which includes inducing mutation by treating a Hyphomicrobium sp. parent strain with N-methyl-N′-nitro-N-nitroguanidine (NTG) and UV rays, and culturing the mutant strain in a medium and selecting a mutant strain with high productivity of pyrroloquinoline quinone. Also, provided is a method of mass-producing pyrroloquinoline quinone, which includes culturing a Hyphomicrobium sp. mutant strain, SWB-P91 (KCTC12695BP), adsorbing pyrroloquinoline quinone in a fermenting culture solution from the fermenting culture solution using an adsorption resin, detaching the adsorbed pyrroloquinoline quinone with an eluent; and recovering pyrroloquinoline quinone by vacuum-evaporating the detached pyrroloquinoline quinone solution.
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