PROCESS FOR N-DEALKYLATION OF TERTIARY AMINES
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United States of America Patent
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Issued Date -
Jun 9, 2016
app pub date -
Feb 11, 2016
filing date -
Feb 11, 2016
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Abstract
The present disclosure provides improved methods for N-dealkylation of tertiary amines, including methods for N-demethylation of alkaloids and opioids, in which the dealkylation reaction is carried out in a solvent comprising a tertiary alcohol. The present disclosure also provides improved processes for preparing semi-synthetic opioids that incorporate the disclosed methods for N-dealkylation of tertiary amines.
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