Entrapment of Radionuclides in Nanoparticle Compositions

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United States of America Patent

APP PUB NO 20160158392A1
SERIAL NO

14968019

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Abstract

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The present invention is directed to the technical field of imaging compositions useful for diagnosing cancer and other diseases in a subject. In particular, the invention relates to a class of diagnostic compounds comprising a novel liposome composition with encapsulated metal entities such as radionuclides, for example 61Cu and 64Cu copper isotopes. The invention further relates to a novel method for loading delivery systems, such as liposome compositions, with metal entities such as radionuclides, and the use of liposomes for targeted diagnosis and treatment of a target site, such as cancerous tissue and, in general, pathological conditions associated with leaky blood vessels. The present invention provides a new diagnostic tool for the utilization of positron emission tomography (PET) imaging technique.

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Patent Owner(s)

Patent OwnerAddress
TECHNICAL UNIVERSITY OF DENMARK2800 LYNGBY
RIGSHOSPITALET2100 COPENHAGEN Ø

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Andresen, Thomas Lars Vanlose, DK 23 70
Henriksen, Jonas Rosager Allerod, DK 13 49
Kjær, Andreas Frederiksberg, DK 13 16
Petersen, Anncatrine Luisa Niva, DK 4 14
Rasmussen, Palle Hedengran Taastrup, DK 6 35

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