PROCESS FOR ISOLATION AND PURIFICATION OF A TARGET PROTEIN FREE OF PRION PROTEIN (PRPSC)
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United States of America Patent
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Dec 29, 2015
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Aug 23, 2007
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Abstract
A process for isolation and purification of a target protein by chromatography wherein the chromatography removes or depletes prions (PrPSc), comprising the steps of
- contacting a potentially PrPSC-contaminated sample comprising a target protein with a multimodal chromatographic material;setting buffer conditions so that the target protein is bound to the multimodal chromatographic material and whereas PrPSC is not binding to the multimodal chromatographic material;followed by elution of the target protein.
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