ONE-PHOTON INTEGRATED NEUROPHOTONIC SYSTEMS
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United States of America Patent
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Issued Date -
Jun 2, 2016
app pub date -
Nov 5, 2014
filing date -
Nov 5, 2014
priority date (Note) -
Abandoned
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Abstract
An apparatus and method for detecting functional cellular activity within a volume of a tissue. The method includes inserting a three-dimensional array of optical emitters and optical detectors into a volume of a tissue, where the tissue volume includes one or more cells labeled with an optical reporter of cellular activity; illuminating the one or more cells with photons from the optical emitters of the three-dimensional array to generate optical signals from the optical reporter that labels the one or more cells; and detecting the optical signals using the optical detectors of the three-dimensional array, where the illumination includes one-photon excitation of the optical reporter.
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