RECEPTORS FOR B7-H4

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United States of America Patent

APP PUB NO 20160146806A1
SERIAL NO

14891867

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Abstract

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Isolated cell surface receptors for B7-H4 have been identified based on function. B7-H4 receptor activation by B7-H4 on the dendritic cell, T follicular helper cell and germinal center B cell membrane stimulates inhibitory signaling in those leukocytes. B7-H4 receptor activation decreases production and/or secretion of proinflammatory cytokines, and promotes anti-inflammatory cytokine by mature DC and T cells. Modulators of B7-H4 receptor polypeptides and methods for their therapeutic use are also provided.

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Patent Owner(s)

Patent OwnerAddress
MEDIMMUNE LLCONE MEDIMMUNE WAY GAITHERSBURG MD 20878

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Langermann, Solomon Baltimore, US 44 1299
Miller, Stephen D Oak Park, US 41 370
Podojil, Joseph R Downers Grove, US 8 69

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