Methods and compositions for targeted genetic modification using paired guide RNAs
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United States of America Patent
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Oct 29, 2019
Grant Date -
May 26, 2016
app pub date -
Nov 20, 2015
filing date -
Nov 21, 2014
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Abstract
Compositions and methods are provided for creating and promoting biallelic targeted modifications to genomes within cells and for producing non-human animals comprising the modified genomes. Also provided are compositions and methods for modifying a genome within a cell that is heterozygous for an allele to become homozygous for that allele. The methods make use of Cas proteins and two or more guide RNAs that target different locations within the same genomic target locus. Also provided are methods of identifying cells with modified genomes.
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