DIAGNOSIS AND TREATMENT OF METABOLIC DISORDERS
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United States of America Patent
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Issued Date -
May 26, 2016
app pub date -
Mar 6, 2014
filing date -
Mar 6, 2013
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Abstract
A method or assay for determining whether an individual is a HNF1A-MODY carrier is described and comprising a step of assaying a biological sample from the individual to detect increased abundance of a micro RNA molecule selected from miR103, miR551b, or miR224, or detect decreased abundance of a micro RNA molecule selected from miR503, and miR539. Increased abundance of one or more of miR103, miR551b, or miR224 or decreased abundance of one or more of miR503 and miR539, indicates that the individual is a HNF1A-MODY carrier. A method for treating metabolic disorders, especially diabetes mellitus, is also described.
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