HER2 polypeptides useful for imaging and monitoring tumors and cancers
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United States of America Patent
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May 12, 2020
Grant Date -
May 26, 2016
app pub date -
Jun 24, 2014
filing date -
Jun 27, 2013
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Abstract
A method of use of an isolated polypeptide conjugated with a radionuclide, wherein the isolated polypeptide binds specifically to HER2, or a variant thereof is described. The method is for monitoring the response to HSP90 inhibition and comprises the use of the isolated polypeptide conjugated with 18F. The application also describes the use of an isolated polypeptide conjugated with 18F, wherein the isolated polypeptide binds specifically to HER2 or variants thereof, as an imaging agent to monitor uptake thereof to measure HSP90 inhibition.
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