Nanoparticles for Encapsulation and Delivery of Bioactive Compounds and Compositions Thereof
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United States of America Patent
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May 26, 2016
app pub date -
Jun 12, 2014
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Jun 12, 2014
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In certain embodiments, this disclosure relates to nanoparticles for drug-delivery of cytotoxic anti-cancer compounds. In certain embodiments, the nanoparticle comprises a maytansinoid and an acetalated polysaccharide-polyethylene glycol conjugate. This disclosure also relates to methods for treatment of infection and cancer are also claimed, wherein a cytotoxic compound is en capsulated in a nanoparticle is degraded at the intended target, but otherwise stable, releasing the cytotoxic compound. Compositions comprising the nanoparticles and cytotoxic drugs are also considered.
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