PEPTIDE-RESIN CONJUGATE AND USE THEREOF
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United States of America Patent
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May 19, 2016
app pub date -
Jun 19, 2014
filing date -
Jun 19, 2014
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Abstract
The present invention relates to a peptide-resin conjugate of Formula (2), wherein: Pr1 is selected from H, alkyl, aryl, aralkyl, acyl, aroyl and a protecting group; Y is a direct bond; or an optionally protected natural or unnatural amino acid residue; or a peptide comprising 2 to 200 natural or unnatural amino acid residues, each of which is optionally protected; Dia is a natural or unnatural diamino acid; A is a polymer resin conjugated to the side chain amino function of the diamino acid; X is an optionally protected natural or unnatural amino acid residue; or a peptide comprising 2 to 15 natural or unnatural amino acid residues, each of which is optionally protected; R1, and R2 are each independently selected from H, alkyl, aryl, aralkyl, NH2, NH—CO—NH2. Further aspects of the invention relate to a process of preparing peptide-resin conjugates of Formula (2), and their use in the preparation of peptides.
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