METHODS OF PREPARING AND USING SERICIN HYDROGEL

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United States of America Patent

SERIAL NO

15003786

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Abstract

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A method for preparing a sericin hydrogel, the method including: 1) weighing a cocoon of a fibroin-deficient mutant silkworm, Bombyx mori, extracting the cocoon by an aqueous solution of LiBr or LiCl, dialyzing an extracted solution to yield a sericin solution having a concentration of a non-degraded sericin of between 0.1 and 4 wt. %; and 2) concentrating the sericin solution to a concentration of between 1.5 and 10 wt. %, adding a crosslinking agent to the concentrated sericin solution at a ratio of between 2 and 500 μL of the crosslinking agent per each milliliter of the sericin solution, fully blending the crosslinking agent with the concentrated sericin solution, and keeping a resulting mixture at the temperature of between 4 and 45° C. for between 5 s and 36 hrs to yield a hydrogel.

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Patent Owner(s)

Patent OwnerAddress
UNION HOSPITAL TONGJI MEDICAL COLLEGE HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY430022 NO 1277 JIEFANG AVENUE JIANGHAN DISTRICT HUBEI WUHAN WUHAN CITY HUBEI PROVINCE 430022

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
HUANG, Lei Wuhan, CN 706 4924
LI, Yongkui Wuhan, CN 2 4
LIU, Jia Wuhan, CN 387 1559
QI, Chao Wuhan, CN 42 448
WANG, Lin Wuhan, CN 481 3933
WANG, Zheng Wuhan, CN 534 5554
YANG, Wen Wuhan, CN 101 340
ZHANG, Yeshun Wuhan, CN 1 2

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