METHOD FOR PREDICTING RESPONSE TO CANCER TREATMENT

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United States of America Patent

APP PUB NO 20160130663A1
SERIAL NO

14904188

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Abstract

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It has been found that BRG1 and BRM have a synthetic-lethal relationship, and that a treatment for inhibiting BRM is a promising approach for treating a BRG1-deficient cancer having no mutation in known therapeutic target genes. Moreover, it has also been revealed that, in this therapeutic strategy, a BRM inhibitor may be administered to a cancer patient after the selection based on BRG1 function suppression, thus enabling an efficient treatment based on the companion diagnosis.

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Patent Owner(s)

Patent OwnerAddress
NATIONAL CANCER CENTERTOKYO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ito, Kentaro Tokyo, JP 38 232
Kohno, Takashi Tokyo, JP 28 346
Tominaga, Yuichi Tokyo, JP 11 89
Tsuta, Koji Tokyo, JP 3 80

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