Materials and Methods for Rescue of Ischemic Tissue and Regeneration of Tissue Integrity During Resection, Engraftment and Transplantation
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United States of America Patent
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May 5, 2016
app pub date -
Oct 29, 2015
filing date -
Oct 30, 2014
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Abstract
Cell-containing implants populated with endothelial cells rescue liver donor and recipient endothelium and parenchyma from ischemic injury after major hepatectomy and engraftment. The inventions disclosed herein highlight the discovery that endothelial-hepatocyte physiologically communicate and cooperate during hepatic repair. The present inventions provide materials and methods for a new approach to improve transplant and regenerative medicine outcomes, for example, liver transplantation.
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