Use of Klotho Nucleic Acids or Proteins for Treatment of Diabetes and Diabetes-Related Conditions
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United States of America Patent
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May 5, 2016
app pub date -
Mar 14, 2014
filing date -
Mar 14, 2013
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Abstract
In one embodiment, the inventive concepts include a method of treating a diabetic condition or a diabetes-related condition in a subject in need of such treatment by administering to the subject a therapeutically-effective amount of a vector comprising a nucleic acid which encodes a klotho protein or a therapeutically-effective portion of a klotho protein, wherein the klotho protein or therapeutically-effective portion of the klotho protein is expressed in vivo in pancreatic beta cells of the subject. In another embodiment, the inventive concepts include a method of treating a diabetic condition or a diabetes-related condition in a subject in need of such treatment by administering to the subject a therapeutically-effective amount of at least one of a klotho protein and a therapeutically-effective portion of the klotho protein.
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