BIOMARKER OF Nrf2 ACTIVATION

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United States of America Patent

APP PUB NO 20160115542A1
SERIAL NO

14894031

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Provided is FGF21 that is a metabolism-related biomarker reflecting the activation of Nrf2 in vivo. Also provided are a method for monitoring a response of a subject to which an Nrf2 activator is administered, said method comprising a step for measuring the FGF21 level, at a point during or after the administration of the Nrf2 activator, in a biosample that is derived from the subject, wherein an increase in the FGF21 level indicates a positive response to the administration of the Nrf2 activator, etc. According to the present invention, a metabolism-related biomarker that reflects the activation of Nrf2 in vivo is provided.

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Patent Owner(s)

Patent OwnerAddress
TOHOKU UNIVERSITY2-1-1 KATAHIRA AOBA-KU SENDAI-SHI MIYAGI 980-8577

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Furusawa, Yuki Tokyo, JP 11 1
Uruno, Akira Miyagi, JP 1 0
Yamamoto, Masayuki Miyagi, JP 380 5148

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges2395234329687311986733701 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +0200400600800100012001400160018002000220024002600

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