BIOMARKER OF Nrf2 ACTIVATION
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United States of America Patent
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N/A
Issued Date -
Apr 28, 2016
app pub date -
May 28, 2014
filing date -
May 29, 2013
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Provided is FGF21 that is a metabolism-related biomarker reflecting the activation of Nrf2 in vivo. Also provided are a method for monitoring a response of a subject to which an Nrf2 activator is administered, said method comprising a step for measuring the FGF21 level, at a point during or after the administration of the Nrf2 activator, in a biosample that is derived from the subject, wherein an increase in the FGF21 level indicates a positive response to the administration of the Nrf2 activator, etc. According to the present invention, a metabolism-related biomarker that reflects the activation of Nrf2 in vivo is provided.
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- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
TOHOKU UNIVERSITY | 2-1-1 KATAHIRA AOBA-KU SENDAI-SHI MIYAGI 980-8577 |
International Classification(s)
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Furusawa, Yuki | Tokyo, JP | 11 | 1 |
# of filed Patents : 11 Total Citations : 1 | |||
Uruno, Akira | Miyagi, JP | 1 | 0 |
# of filed Patents : 1 Total Citations : 0 | |||
Yamamoto, Masayuki | Miyagi, JP | 380 | 5148 |
# of filed Patents : 380 Total Citations : 5148 |
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