CHIMERIC FVII-XTEN MOLECULES AND USES THEREOF
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United States of America Patent
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Issued Date -
Apr 28, 2016
app pub date -
May 30, 2014
filing date -
May 31, 2013
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Abandoned
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Abstract
The present invention provides chimeric FVII molecules comprising FVII, an XTEN polypeptide, and an antibody C and antigen-binding molecules thereof which specifically bind the α and/or β subunits of the non-active form of the GPIIb/IIIIa receptor. The antibodies and antigen-binding molecules can be genetically fused and/or conjugated to heterologous moieties, e.g., half-life extending moiety. The invention also includes methods of producing and using the chimeric molecules.
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