CELL SENESCENCE MARKERS AS DIAGNOSTIC AND THERAPEUTIC TARGETS
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United States of America Patent
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app pub date -
May 26, 2014
filing date -
May 24, 2013
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Abstract
Provided are methods and agents for depleting senescent cells endogenous to a subject, involving administering to the subject a binding agent that is selectively toxic to senescent cells in an amount effective to reduce the number of such cells, wherein the binding agent binds selectively to a senescent cell surface protein having a misfolded conformation, relative to said protein in a native conformation.
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