BMP INHIBITORS AND METHODS OF USE THEREOF

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United States of America Patent

APP PUB NO 20160115167A1
SERIAL NO

14772630

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.

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Patent Owner(s)

Patent OwnerAddress
THE GENERAL HOSPITAL CORPORATION55 FRUIT ST BOSTON MA 02114

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bloch, Kenneth D Chestnut Hill, US 22 277
Cuny, Gregory D Houston, US 85 957
Mohedas, Agustin H Somerville, US 6 17
Peterson, Randall T Belmont, US 17 95
Yu, Paul B Boston, US 24 128

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  • 7 Citation Count
  • C07D Class
  • 36.67 % this patent is cited more than
  • 9 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges137619812528031834145701 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +0100200300400500600700800900100011001200130014001500160017001800190020002100

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