Heparosan/Therapeutic Prodrug Complexes and Methods of Making and Using Same
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United States of America Patent
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Issued Date -
Apr 28, 2016
app pub date -
Oct 23, 2015
filing date -
Oct 23, 2014
priority date (Note) -
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Abstract
Compositions, methods, and systems are disclosed for the development and use of heparosan, a natural polymer related to heparin, as a new therapeutic modifying agent or complexation vehicle which can modulate drug cargo pharmacokinetics and behavior within a mammalian patient. In certain non-limiting embodiments, the use of heparosan is complexed with anti-cancer drugs and the like, thus forming a prodrug for the purposes of increasing efficacy and reducing side effects compared to the parental drug alone.
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