CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS

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United States of America Patent

APP PUB NO 20160114000A1
SERIAL NO

14920012

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Abstract

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Described are peptide analogs of glucagon, which have been modified to be resistant to cleavage and inactivation by dipeptidyl peptidase IV (DPP-IV) and to increase in vivo half-life of the peptide analog while enabling the peptide analog to have relatively balanced agonist activity at the glucagon-like peptide 1 (GLP-1) receptor and the glucagon (GCG) receptor, and the use of such GLP-1 receptor/GCG receptor co-agonists for treatment of metabolic disorders such as diabetes, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and obesity.

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Patent Owner(s)

Patent OwnerAddress
PEPTIPHARMA S R LVIALE CITTA D' EUROPA 679 ROMA 00144

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bianchi, Elisabetta Pomezia, IT 54 263
Carrington, Paul E Hillsborough, US 8 6
Deng, Qiaolin Edison, US 31 115
Nargund, Ravi East Brunswick, US 42 368
Orvieto, Federica Pomezia, IT 22 158
Palani, Anandan Bridgewater, US 108 651
Pessi, Antonello Roma, IT 44 280
Tucker, Thomas Joseph North Wales, US 17 43
Wu, Chengwei Ambler, US 19 36

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