PREVENTION AND TREATMENT OF ATRIAL FIBRILLATION

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United States of America Patent

APP PUB NO 20160108431A1
SERIAL NO

14895468

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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There is provided a nucleic acid that inhibits miR-31 in an atrial myocyte, for use in the prevention or treatment of atrial fibrillation in a subject. Also provided is a method for diagnosing or predicting the risk of atrial fibrillation in a subject, said method comprising: (i) determining the amount of miR-31 in a sample from the subject; (ii) comparing the amount of miR-31 in the sample with a reference standard; and (iii) identifying a difference in the amount of miR-31 in the sample relative to the reference standard; wherein an increase in the amount of miR-31 in the sample compared to the reference standard correlates with the presence of or an increased risk of atrial fibrillation in the subject; and wherein a decrease, or no difference in the amount of miR-31 in the sample compared to the reference standard correlates with the absence of an increased risk of atrial fibrillation in the subject.

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Patent Owner(s)

Patent OwnerAddress
OXFORD UNIVERSITY INNOVATION LIMITEDBOTLEY OXFORDSHIRE OX2 0JB

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  • 2014 Application Filing Year
  • C12N Class
  • 5730 Applications Filed
  • 4275 Patents Issued To-Date
  • 74.61 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances201420152016201720182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Casadei, Barbara Oxford, GB 1 0
Reilly, Svetlana Oxford, GB 1 0

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges4317336334866191291232201 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +02505007501000125015001750200022502500275030003250350037504000425045004750

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