COMBINATION OF CD37 ANTIBODIES WITH CHLORAMBUCIL
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United States of America Patent
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Apr 21, 2016
app pub date -
Jun 14, 2013
filing date -
Jun 14, 2013
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Abstract
The present invention relates to immunotherapies that are based on depletion of CD37-positive cells such as B-cells. The present invention provides methods for reduction of CD37-positive cells such as B-cells in an individual/patient using a combination of CD37 antibody/antibodies and chlorambucil. The combination of CD37 antibodies and chlorambucilis shown to have a synergistic effect. The application further provides materials and methods for treatment of diseases involving aberrant B-cell activity.
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