CMP-ACETYLNEURAMINIC ACID HYDROXYLASE TARGETING VECTOR, TRANSGENIC ANIMAL FOR XENOTRANSPLANTATION INTRODUCED WITH THE VECTOR, AND METHOD OF MANUFACTURING THE SAME
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United States of America Patent
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Apr 14, 2016
app pub date -
Aug 23, 2013
filing date -
Apr 30, 2013
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Abstract
There is provided a CMP-acetylneuraminic acid hydroxylase targeting vector, a transgenic animal for xenotransplantation introduced with the vector, and a method of manufacturing the same. The targeting vector and the cell line for transformation prepared by the present invention can be used for the efficient production of cloned pigs for xenotransplantation by the complex regulation of the expression of the genes involved in the immunological rejection responses.
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