BINDING MEMBERS-513
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United States of America Patent
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Issued Date -
Apr 7, 2016
app pub date -
Oct 23, 2015
filing date -
Oct 23, 2015
priority date (Note) -
Abandoned
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Abstract
This invention relates to binding members, especially antibody molecules, specific for interleukin 1 receptor 1 (IL-1R1). For example, isolated binding members specific for IL-1R1 which competes with IL-1 and IL-1Ra for binding to IL-1R1 and binds Il-1R1 with a KD of 10 pM or less when measured by Kinexa™. The binding members are useful for, inter alia, treatment of disorders mediated by IL-1R1 including rheumatoid arthritis, asthma and chronic obstructive pulmonary disease (COPD).
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