TARGETED POLYMERIC CONJUGATES AND USES THEREOF
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United States of America Patent
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Issued Date -
Apr 7, 2016
app pub date -
Dec 16, 2015
filing date -
Dec 16, 2015
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Abstract
Polymeric conjugates comprising a polymeric backbone having attached thereto a bone targeting moiety and a therapeutically active agent, wherein the bone targeting moiety is attached to one end of the polymeric backbone via a branching unit such that a molar ratio of the bone targeting moiety to the polymer is at least 2:1, are disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of bone related disorders are also disclosed.
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