Antibodies to Carcinoembryonic Antigen (CEA), Methods of Making Same, and Uses Thereof
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United States of America Patent
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Issued Date -
Mar 17, 2016
app pub date -
May 26, 2015
filing date -
Aug 31, 2009
priority date (Note) -
Abandoned
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Abstract
The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies or variants thereof specific for cell surface or membrane bound human CEA. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs of the invention, and to methods of using these ABMs in treatment of disease. In addition, the present invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.
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