STAPHYLOCOCCUS LIVE CELL VACCINES
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United States of America Patent
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N/A
Issued Date -
Mar 17, 2016
app pub date -
May 2, 2014
filing date -
May 3, 2013
priority date (Note) -
Published
status (Latency Note)
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Abstract
Staphylococcus aureus protein A variants, defective in immunoglobulin binding, elicit protective immunity against staphylococcal disease. The present invention includes methods for preventing or ameliorating staphylococcal infections, particularly hospital acquired nosocomial infections. As such, the invention contemplates vaccines for use in both active and passive immunization embodiments. In certain embodiments the vaccine is an isolated recombinant staphylococcal bacteria that expresses a variant Protein A (SpA variant) comprising (a) at least one amino acid substitution that disrupts Fc binding and (b) at least a second amino acid substitution that disrupts VH3 binding variant in at least one of SpA A, B, C, D, and/or E domains.
First Claim
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Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
THE UNIVERSITY OF CHICAGO | 5801 S ELLIS AVENUE CHICAGO IL 60637 |
International Classification(s)
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
FALUGI, Fabiana | Chicago, US | 4 | 22 |
# of filed Patents : 4 Total Citations : 22 | |||
KIM, Hwan Keun | Chicago, US | 21 | 328 |
# of filed Patents : 21 Total Citations : 328 | |||
MISSIAKAS, Dominique | Chicago, US | 13 | 51 |
# of filed Patents : 13 Total Citations : 51 | |||
SCHNEEWIND, Olaf | Chicago, US | 47 | 716 |
# of filed Patents : 47 Total Citations : 716 |
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Patent Citation Ranking
- 3 Citation Count
- A61K Class
- 38.16 % this patent is cited more than
- 9 Age
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Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
---|---|---|---|---|
11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Sep 17, 2027 |
Fee | Large entity fee | small entity fee | micro entity fee |
---|---|---|---|
Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
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