METHODS AND COMPOSITIONS FOR INHIBITING HUMAN COPPER TRAFFICKING PROTEINS ATOX1 AND CCS

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United States of America Patent

SERIAL NO

14762980

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Compositions and methods concern organic molecules that bind to human Atox1 and CCS at the copper trafficking interface of these proteins. This binding suppresses copper trafficking, which leads to inhibition of cancer cell proliferation and tumor growth. In addition to serving as an effective treatment of cancer, these organic molecules inhibit cellular copper uptake and can be used as treatment of disorders of copper metabolism such as Wilson's disease, which is characterized by copper overload, as well as wound healing.

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THE UNIVERSITY OF CHICAGO5801 SOUTH ELLIS AVENUE CHICAGO IL 60637

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
HE, Chuan Chicago, US 143 1886
JIANG, Hualiang Shanghai, CN 58 37
LIU, Hong Shanghai, CN 550 3045
LU, Junyan Shanghai, CN 1 4
LUO, Cheng Shanghai, CN 108 335
WANG, Jing Chicago, US 1745 13464

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