A METHOD FOR GENERATING INDUCED PLURIPOTENT STEM CELLS
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United States of America Patent
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Mar 10, 2016
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Apr 16, 2014
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Apr 16, 2013
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Abstract
The invention relates to a method for generating induced pluripotent stem cells, wherein the method comprises: step a) of inducing non-pluripotent cells to produce a mixture comprising induced pluripotent stem cells and non-pluripotent cells; step b) of contacting the mixture comprising induced pluripotent stem cells and non-pluripotent cells obtainable from step a) with a binding agent, wherein the binding agent is capable of binding an epitope consisting of the non-reducing terminal saccharide structure according to formula (Fucα1-2)aGalβ1-3HexNAcβ, wherein a=0 or 1 and Hex is either Glc or Gal; and step c) of selecting an induced pluripotent stem cell bound by the binding agent.
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