PERFORIN 2 DEFENSE AGAINST INVASIVE AND MULTIDRUG RESISTANT PATHOGENS
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United States of America Patent
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Issued Date -
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app pub date -
Mar 15, 2013
filing date -
Apr 24, 2012
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Perforin-2 (P2) is expressed by fibroblasts, microglia and macrophages and was found to be responsible for killing bacteria, for example, Mycobacteria smegmatis, M. avium, Salmonellae, MRSA (drug resistant Stapholococci), E coli. Compounds identified by screening assays are selected based on the effects of these compounds on P2. Use of these compounds in the treatment of infectious diseases, in particular, bacteria and antibiotic-resistant bacteria is also provided.
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Family
Country | kind | publication No. | Filing Date | Type | Sub-Type |
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- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
- UNIVERSITY OF MIAMI
International Classification(s)

- 2013 Application Filing Year
- A61K Class
- 12711 Applications Filed
- 11051 Patents Issued To-Date
- 86.95 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
De, Armas Lesley | N. Bay Village, US | 2 | 6 |
# of filed Patents : 2 Total Citations : 6 | |||
Lyapichev, Kirill | Miami, US | 2 | 6 |
# of filed Patents : 2 Total Citations : 6 | |||
McCormack, Ryan | Miami, US | 4 | 10 |
# of filed Patents : 4 Total Citations : 10 | |||
Podack, Eckhard | Coconut Grove, US | 5 | 50 |
# of filed Patents : 5 Total Citations : 50 |
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Patent Citation Ranking
- 2 Citation Count
- A61K Class
- 38.16 % this patent is cited more than
- 9 Age
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- No Forward Cites to Display

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