METHODS FOR IDENTIFYING PROTEINS AND COMPOUNDS THAT MODULATE THE ACTIVITY OF OTUB1
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United States of America Patent
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Issued Date -
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app pub date -
Apr 14, 2014
filing date -
Apr 19, 2013
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Abandoned
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Abstract
The present invention describes that OTUB1 cleavage of K48 poly-ubiquitin is stimulated by a select subset of E2 enzymes, and that this stimulation is regulated by the ubiquitin-charged state of the E2 and free ubiquitin. Structural and biochemical studies of OTUB1 and UBCH5B show that the E2 stimulates binding of the polyubiquitin substrate by contacting the OTUB1 N-terminal ubiquitin-binding helix. Methods for identifying E2 enzymes which stimulate or inhibit cleavage of K48 polyubiquitin, as well as novel target compounds which modulate this interaction are provided.
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- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
THE JOHNS HOPKINS UNIVERSITY | 3400 N CHARLES STREET BALTIMORE MARYLAND 21218 UNITED STATES OF AMERICA |
International Classification(s)

- 2014 Application Filing Year
- C12Q Class
- 3114 Applications Filed
- 2141 Patents Issued To-Date
- 68.76 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Dibello, Anthony | Baltimore, US | 2 | 6 |
# of filed Patents : 2 Total Citations : 6 | |||
Wiener, Reuven | Herzeliya, IL | 1 | 0 |
# of filed Patents : 1 Total Citations : 0 | |||
Wolberger, Cynthia | Baltimore, US | 3 | 2 |
# of filed Patents : 3 Total Citations : 2 |
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- C12Q Class
- 0 % this patent is cited more than
- 9 Age
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