Composition comprising at least two influenza A virus-neutralizing-binding molecules

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United States of America Patent

PATENT NO 10703802
APP PUB NO 20160052997A1
SERIAL NO

14780682

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Abstract

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The present invention provides a composition comprising at least two influenza A virus-neutralizing binding molecules that bind to an epitope in the stem region of influenza A virus hemagglutinin (HA) protein, the method comprising: i) a first binding molecule capable of neutralizing at least one influenza A virus subtype selected from the group consisting of H1, H2, H5 and H9; ii) a second binding molecule capable of neutralizing at least one influenza A virus subtype selected from the group consisting of H1, H3, H5, H7 and H9. The mixed composition of the present invention can effectively neutralize the multiple influenza subtypes of both phylogenetic group 1 and phylogenetic group 2 and can be used in combination with a chemical compound. Thus, the composition of the present invention is very useful for the prevention and treatment of a disease by influenza virus.

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Patent Owner(s)

Patent OwnerAddress
CELLTRION INCINCHON SOUTH KOREA INCHEON

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chang, Shin Jae Incheon, KR 13 34
Cho, Myung Sam Incheon, KR 2 21
Hong, Seung Suh Seoul, KR 10 28
Kim, Sung Hwan Incheon, KR 168 718
Kwon, Ki Sung Seoul, KR 16 44
Lee, Eun Beom Seoul, KR 1 7
Lee, Jae Won Gyeonggi-do, KR 198 2182
Lee, So Jung Incheon, KR 12 31
Shin, Ji Young Incheon, KR 19 280
Yi, Kye Sook Incheon, KR 7 31

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