COMPOSITIONS TO ALLEVIATE PRESYSTEMIC METABOLISM OF OPIOIDS

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United States of America Patent

APP PUB NO 20160051536A1
SERIAL NO

14781683

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Compositions comprising one or more opioids and one or more inhibitors of uridine diphosphate glucuronosyl transferases (UGTs) are provided. The inhibitors decrease the presystemic metabolism of the one or more opioids, thereby increasing their bioavailability. The inhibitors are compounds that are designated as Generally Regarded as Safe (GRAS) and/or “Everything Added to Food” (EAF) and/or are dietary supplements. Methods of alleviating pain and of treating opiate addiction in a subject by administering the compositions are also provided.

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Patent Owner(s)

Patent OwnerAddress
VIRGINIA COMMONWEALTH UNIVERSITY800 EAST LEIGH STREET SUITE 113 RICHMOND VA 23219

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
GERK, Phillip M Richmond, US 3 18
NASSER, Azmi Richmond, US 8 15

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