Materials and Methods Useful For Affecting Tumor Cell Growth, Migration and Invasion
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United States of America Patent
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Issued Date -
Feb 18, 2016
app pub date -
Oct 26, 2015
filing date -
Nov 23, 2009
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Abstract
It is disclosed herein that miR-221 and miR-222 down-regulate PTEN and TIMP3 tumor suppressors, resulting in TRAIL resistance. The present invention provides research, diagnostic, and therapeutic tools and methods related to this discovery. Diagnostics, prognostics and treatments for human hepatocellular cancer and non-small cell lung carcinoma having a TRAIL resistance are particularly described herein.
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