HAMMERHEAD RIBOZYMES
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United States of America Patent
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Issued Date -
Feb 18, 2016
app pub date -
Mar 26, 2014
filing date -
Mar 27, 2013
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Abstract
The object of the invention are hammerhead ribozymes directed against the sequence of miR-21 and/or miR-21 precursors, having the ability to specifically cleave miR-21 and/or miR-21 precursors, and wherein they have a catalytic core with a sequence as shown in SEQ ID No 1. The invention also relates to a composition comprising such ribozymes, a therapeutic agent comprising them, a use of such ribozymes and a method of selective cleavage of miR-21 and/or miR-21 precursors employing such ribozymes.
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