IN VITRO SYSTEM FOR GENERATION OF ANTIGEN-SPECIFIC IMMUNE RESPONSES
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United States of America Patent
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Issued Date -
Feb 18, 2016
app pub date -
Feb 3, 2015
filing date -
Feb 3, 2014
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Abstract
The present invention describes methods to produce vaccines and antibodies, which methods including contacting follicular dendritic cells (FDC) with naïve B-cells to mimic conditions in the germinal center (CG) in vitro, including methods of enhancing antibody production in hybridoma cells and compositions comprising product of the instant methods.
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