COMPOSITE FORMULATION COMPRISING A FILM COATING LAYER CONTAINING ROSUVASTATIN OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
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United States of America Patent
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Issued Date -
Feb 18, 2016
app pub date -
Apr 30, 2014
filing date -
May 6, 2013
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Abstract
Provided is a composite formulation comprising: (i) a core including a first pharmacological component; and (ii) a film coating layer formed on a surface of the core, which contains rosuvastatin or a pharmaceutically acceptable salt thereof as a second pharmacological component and a polyvinyl alcohol-polyethylene glycol graft copolymer and polyvinyl alcohol as a coating material. In the composite formulation of the present invention, tension and fluidity of the film coating layer are excellent, and thus breakage and a defective ratio are low. Accordingly, a composite agent containing rosuvastatin effective to relieve and treat a hyperlipemia symptom, or its pharmaceutically acceptable salt can be provided with high efficiency, and is present in a composite formulation form, and thus compliance of a patient can be improved.
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