NMR ASSAY TO SCREEN PROTEIN-PROTEIN INTERACTION INHIBITORS

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United States of America Patent

APP PUB NO 20160041181A1
SERIAL NO

14765626

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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This invention relates generally to a field of rational drug design. In particular, the present invention relates to a 19 F NMR assay for screening inhibitors of specific protein-target interactions, preferably those that inhibit influenza A NS 1 protein and can be useful in treating influenza A viral infections. The invention also relates to agents, compositions, and methods for treating influenza A viral infections.

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Patent Owner(s)

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RUTGERS THE STATE UNIVERSITY OF NEW JERSEY83 SOMERSET STREET NEW BRUNSWICK NJ 08901

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Annavarapu, Srinivas Somerset, US 1 0
Aramini, James M Glenside, US 1 0
Hamilton, Keith Brick, US 22 157
Ma, Lichung South Princeton Junction, US 3 18
Montelione, Gaetano T Highland Park, US 15 22
Nanda, Vikas Highland Park, US 4 1
Nosker, Patrick L Stockton, US 4 5
Pike, Douglas Somerset, US 3 1

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