SYSTEMS AND METHODS FOR FACILITATING DIAGNOSIS, PROGNOSIS AND TREATMENT OF CANCER BASED ON DETECTION OF HER3 ACTIVATION
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United States of America Patent
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Feb 11, 2016
app pub date -
Apr 7, 2014
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Apr 5, 2013
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Systems and methods are provided for facilitating diagnosis, prognosis and treatment of cancer based on detection of HER3 activation. The systems and methods involve analysis of samples for the presence or the absence of activated HER3 markers as indicated by HER2-HER3 heterodimers, HER3 phosphorylation, or recruitment of PI3K to activated HER3 (HER3/PI3K complexes). The amounts of activated HER3 marker expression may be measured alone or in conjunction with other biomarkers.
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