IMMUNOLOGICAL CONTROL OF BETA-AMYLOID LEVELS IN VIVO
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United States of America Patent
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Issued Date -
Feb 11, 2016
app pub date -
Apr 16, 2015
filing date -
Jun 16, 1999
priority date (Note) -
Abandoned
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Abstract
Disclosed herein are compositions and methods useful for controlling β-amyloid levels. In particular, the instant invention relates to an antibody that catalyzes hydrolysis of β-amyloid at a predetermined amide linkage are provided. The present invention also provides a vectorized antibody that is capable of crossing the blood brain barrier and is also capable of catalyzing the hydrolysis of β-amyloid at a predetermined amide linkage. Also provided are methods for modulating β-amyloid levels in vivo using antibodies that bind to β-amyloid. These compositions and methods have therapeutic applications, including the treatment of Alzheimer's disease.
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