Virus-like Particle Vaccines

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United States of America Patent

SERIAL NO

14819684

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Abstract

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The invention is directed to dimeric fusion proteins and virus-like particles comprising such dimeric fusion proteins. These dimeric fusion proteins comprise an antigen or antigenic fragment carried between two viral structural proteins or fragments thereof, with or without linkers, in a manner that, relative to traditional monomeric platforms, minimizes steric hindrance among the antigen or antigenic fragment and the viral structural proteins or fragments thereof. This novel design provides for multivalent vaccines and enhanced immunogenicity. The invention also relates to nucleic acids encoding such dimeric fusion proteins and host cells comprising such nucleic acids. The invention further relates to pharmaceutical compositions comprising the dimeric fusion proteins and/or virus-like particles of the invention, and methods of prevention or treatment using such compositions.

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Patent Owner(s)

Patent OwnerAddress
MEDIGEN BIOTECHNOLOGY CORPORATION5F NO 611 SEC 1 WANSHOU ROAD GUEISHAN TOWNSHIP TAOYUAN COUNTY 333

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Ming-Cheng New Taipei City, TW 17 46
Cheng, Jinyi Taipei City, TW 2 3
Chiang, Ya-Lin New Taipei City, TW 3 6
Lai, Kuei-Tai A New Taipei City, TW 2 3
Lin, Young-Sun Taipei City, TW 9 41
Yang, Chih Ya Taipei City, TW 2 3

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