MAMMALIAN PROTEIN CO-RECOGNITION BY BROADLY NEUTRALIZING ANTIBODIES AS MODIFIED IMMUNOGENS FOR RE-ELICITATION
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Jul 30, 2015
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Aug 1, 2014
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The present invention relates to using HIV-1 broadly neutralizing antibodies to screen for glycan-dependent or protein-dependent self reactivities inherent in these mutated antibodies, and defining this cross recognition at the molecular level, and utilizing the information to re-elicit trimer-specific and/or N-glycan-dependent or protein-surface-dependent broadly neutralizing antibodies and therapeutic applications thereof.
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