USE OF POLYCLONAL AND MONOCLONAL ANTIBODIES SPECIFIC FOR 3-PHOSPHOHISTIDINE

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United States of America Patent

SERIAL NO

14789811

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Abstract

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Isolated monoclonal antibodies and antigen binding fragments are disclosed herein that specifically bind polypeptides comprising a histidine phosphorylated at N3 (3-pHis). Nucleic acids encoding these antibodies, vectors including these nucleic acids, and host cells transformed with these vectors and nucleic acids are also disclosed. Methods are also disclosed for using these antibodies, such as for detection of polypeptides comprising a histidine phosphorylated at N3 (3-pHis), detection of a tumor, monitoring the effectiveness of therapeutic agent, and identifying antibiotics. In some embodiments, the methods can be used to investigate signal transduction pathways.

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Patent Owner(s)

Patent OwnerAddress
SALK INSTITUTE FOR BIOLOGICAL STUDIES10010 N TORREY PINES ROAD LA JOLLA CA 92037-1002

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fuhs, Stephen Rush San Diego, US 4 2
Hunter, Tony Del Mar, US 20 119
Meisenhelder, Jill Vista, US 4 2

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