METHODS AND DEVICES FOR MECHANICAL AND ELECTRICAL STIMULATION OF STEM CELL MONOLAYER AND 3D CULTURES FOR TISSUE ENGINEERING APPLICATIONS
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United States of America Patent
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Feb 4, 2016
app pub date -
Jun 13, 2012
filing date -
Jun 13, 2012
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Abstract
Devices and methods for stimulating mechanically or electromechanically stem cell monolayer and 3D cultures for tissue engineering applications are disclosed. A bracket is proposed to be used in a disposable stimulation device. A disposable stimulation device is also proposed for accommodating a cell culture in a flexible area. Finally, an apparatus is proposed to mechanically extend the disposable stimulation device to induce mechanical stimulation. Additionally, a pair of electrodes placed at two opposing sides of the flexible area creates an electric field to induce electrical stimulation. Accordingly, a method to stimulate electromechanically a cell culture is proposed.
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