DETECTION OF ACUTE RENAL ALLOGRAFT REJECTION
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United States of America Patent
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N/A
Issued Date -
Feb 4, 2016
app pub date -
Mar 13, 2014
filing date -
Mar 15, 2013
priority date (Note) -
Published
status (Latency Note)
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Abstract
The invention provides a method of detecting acute renal allograft rejection in a subject as well as a method of stratifying a subject received a renal allograft and undergoing immunosuppressive therapy for alteration of the therapy. These methods comprise administering to the subject a probe capable of specifically binding to T lymphocytes, the probe being detectable by ultrasound. An allotransplanted kidney of the subject is exposed to ultrasound. The level of T lymphocytes in the kidney is detected. An elevated level of T lymphocytes in the kidney indicates an increased risk of renal allograft rejection and/or that the subject is in need of an alteration of the immunosuppressive therapy.
First Claim
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Family
| Country | kind | publication No. | Filing Date |
|---|---|---|---|
| WO | A1 | WO2014140197 | Mar 13, 2014 |
| AU | A1 | AU2014230447 | Mar 13, 2014 |
| CA | A1 | CA2903968 | Mar 13, 2014 |
| EP | A1 | EP2972387 | Mar 13, 2014 |
International Classification(s)
- 2014 Application Filing Year
- A61K Class
- 14144 Applications Filed
- 11600 Patents Issued To-Date
- 82.02 % Issued To-Date
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- 0 Citation Count
- A61K Class
- 0 % this patent is cited more than
- 9 Age